Roc, a Ras/GTPase domain in complex proteins
نویسندگان
چکیده
منابع مشابه
RasGTPase-activating protein
Abbreviations: GAP, RasGTPase-activating protein; ET, etoposide; NFκB, nuclear factor κB; NSCLC, non-small cell lung carcinoma; PARP, poly(ADP-ribose) polymerase; PDK, 3phospho-inositide-dependent kinase; PI 3-kinase, phosphatidylinositol 3-kinase; SCLC, small cell lung carcinoma; ST, staurosporine ; a . # Oxford University Press ll rights reserved 200 arcinogenesis C Carcinogenesis Advance Acc...
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Ontology construction is a labour-intensive and costly process. Even though many formal and semi-formal vocabularies are available, creating an ontology for a specific application is hindered in a number of ways. Firstly, the process of elicitating concepts is a time consuming and strenuous process. Secondly, it is difficult to keep focus. Thirdly, technical modelling constructs are hard to und...
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Abiotic stresses are the most important factors that reduce the yield of crops. In this case, Bioinformatics analysis plays an important role to study genes, and their relatedness as well as prediction their function in response to abiotic stresses. Among all domains, ARID-PHD domain has been identified in plants and animals and has a very significant role in growth regulation, cell cycle, and ...
متن کاملBiochemical and functional characterization of the ROC domain of DAPK establishes a new paradigm of GTP regulation in ROCO proteins.
DAPK (death-associated protein kinase) is a newly recognized member of the mammalian family of ROCO proteins, characterized by common ROC (Ras of complex proteins) and COR (C-terminal of ROC) domains. In the present paper, we review our recent work showing that DAPK is functionally a ROCO protein; its ROC domain binds and hydrolyses GTP. Furthermore, GTP binding regulates DAPK catalytic activit...
متن کاملIdentifying Determinants of Cullin Binding Specificity Among the Three Functionally Different Drosophila melanogaster Roc Proteins via Domain Swapping
BACKGROUND Cullin-dependent E3 ubiquitin ligases (CDL) are key regulators of protein destruction that participate in a wide range of cell biological processes. The Roc subunit of CDL contains an evolutionarily conserved RING domain that binds ubiquitin charged E2 and is essential for ubiquitylation. Drosophila melanogaster contains three highly related Roc proteins: Roc1a and Roc2, which are co...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2003
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2003.08.008